abstract：:Many natural sounds such as speech contain concurrent amplitude and frequency modulation (AM and FM), with the FM components often in the form of directional frequency sweeps or glides. Most studies of modulation coding, however, have employed one modulation type in stationary carriers, and in cases where mixed-modula...

journal_title：Hearing research

authors： Hsieh IH,Saberi K

更新日期：2010-04-01 00:00:00

abstract：:The purpose of this study was to compare cortical brain responses evoked by amplitude modulated acoustic beats of 3 and 6 Hz in tones of 250 and 1000 Hz with those evoked by their binaural beats counterparts in unmodulated tones to indicate whether the cortical processes involved differ. Event-related potentials (ERPs...

journal_title：Hearing research

authors： Pratt H,Starr A,Michalewski HJ,Dimitrijevic A,Bleich N,Mittelman N

更新日期：2010-04-01 00:00:00

abstract：:Hair cells of the lateral line system in fish may differ in their susceptibility to damage by aminoglycoside antibiotics. Gentamicin has been reported to damage hair cells within canal neuromasts, but not those within superficial neuromasts. This finding, based on SEM imaging, indicates a distinction in the physiology...

journal_title：Hearing research

authors： Van Trump WJ,Coombs S,Duncan K,McHenry MJ

更新日期：2010-03-01 00:00:00

abstract：:Caloric restriction (CR) slows aging in many species and protects some animals from age-related hearing loss (ARHL), but the effect on humans is not yet known. Because rhesus monkeys are long-lived primates that are phylogenically closer to humans than other research animals are, they provide a better model for studyi...

journal_title：Hearing research

authors： Fowler CG,Chiasson KB,Leslie TH,Thomas D,Beasley TM,Kemnitz JW,Weindruch R

更新日期：2010-03-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Hearing research

authors： Hudspeth AJ,Martin P

更新日期：2010-01-30 00:00:00

abstract：BACKGROUND:Epidemiological studies have shown that women have better high-frequency thresholds than men in virtually all age groups, and that age-related hearing decline starts after 30 in men but not until after the age of 50 in women. This coincides with the menopausal transition in most women, thus leading us to hyp...

journal_title：Hearing research

authors： Hederstierna C,Hultcrantz M,Collins A,Rosenhall U

更新日期：2010-01-01 00:00:00

abstract：:Exposure to harsh environment induces stress reactions that increase probability of survival. Stress influences the endocrine, nervous and immune systems and affects the functioning of a variety of organs. Numerous researchers demonstrated that a 24-h exposure to an acoustic rodent repellent provokes stress reaction i...

journal_title：Hearing research

authors： Mazurek B,Haupt H,Joachim R,Klapp BF,Stöver T,Szczepek AJ

更新日期：2010-01-01 00:00:00

abstract：:The cochlear nucleus (CN) is the first sound processing center in the central auditory system that receives the almost unprocessed auditory information from the auditory periphery. The functional organization of the CN has been studied to a great extent in many mammals, including the cat, rat and bat. Yet, despite the...

journal_title：Hearing research

authors： Luo F,Wang Q,Farid N,Liu X,Yan J

更新日期：2009-11-01 00:00:00

abstract：:This study examined the neural basis of auditory selective attention using functional magnetic resonance imaging. The main hypothesis stated that attending to a particular sound frequency would significantly enhance the neural response within those tonotopic regions of the auditory cortex sensitive to that frequency. ...

journal_title：Hearing research

authors： Paltoglou AE,Sumner CJ,Hall DA

更新日期：2009-11-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Hearing research

authors： Brownell WE

更新日期：2009-10-07 00:00:00

abstract：:Electrophysiological recordings in the dorsal cochlear nucleus (DCN) were conducted to determine the nature of changes in single unit activity following intense sound exposure and how they relate to changes in multiunit activity. Single and multiunit spontaneous discharge rates and auditory response properties were re...

journal_title：Hearing research

authors： Finlayson PG,Kaltenbach JA

更新日期：2009-10-01 00:00:00

abstract：:Inner ear damage may lead to structural changes in the central auditory system. In rat and chinchilla, cochlear ablation and noise trauma result in fiber growth and synaptogenesis in the ventral cochlear nucleus (VCN). In this study, we documented the relationship between carboplatin-induced hair cell degeneration and...

journal_title：Hearing research

authors： Kraus KS,Ding D,Zhou Y,Salvi RJ

更新日期：2009-09-01 00:00:00

abstract：:Sodium salicylate (SS) can penetrate the blood-brain barrier to target neurons in the central auditory system. Understanding how SS alters functional behaviors of different types of central auditory neurons will provide insights into the neural mechanisms of SS-induced tinnitus. Here, we report the differential effect...

journal_title：Hearing research

authors： Su YY,Luo B,Wang HT,Chen L

更新日期：2009-07-01 00:00:00

abstract：:Mice of the C57BL/6J (B6) inbred strain exhibit genetic progressive sensorineural hearing loss and have been widely used as a model of adult-onset hearing loss and presbycusis. Males and females exhibit similar degrees of hearing loss until about 3 months of age, after which, the loss accelerates in females. This pape...

journal_title：Hearing research

authors： Willott JF

更新日期：2009-06-01 00:00:00

abstract：:Otoacoustic emissions (OAEs) differ between the sexes in humans, rhesus and marmoset monkeys, and sheep. OAEs also are different in a number of special populations of humans. Those basic findings are reviewed and discussed in the context of possible prenatal-androgen effects on the auditory system. A parsimonious expl...

journal_title：Hearing research

authors： McFadden D

更新日期：2009-06-01 00:00:00

abstract：:Estrogen signaling in auditory and vestibular sensory epithelia is a newly emerging focus propelled by the role of estrogen signaling in many other proliferative systems. Understanding the pathways with which estrogen interacts can provide a means to identify how estrogen may modulate proliferative signaling in inner ...

journal_title：Hearing research

authors： McCullar JS,Oesterle EC

更新日期：2009-06-01 00:00:00

abstract：INTRODUCTION:Distortion product otoacoustic emissions (DPOAEs) are known to represent the contractile amplifier function of cochlear outer hair cells. It is known that low or absent DPOAEs are associated with hearing loss on audiograms. However, low DPOAEs can also be found associated with normal audiograms. It is unkn...

journal_title：Hearing research

authors： Job A,Raynal M,Kossowski M,Studler M,Ghernaouti C,Baffioni-Venturi A,Roux A,Darolles C,Guelorget A

更新日期：2009-05-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Hearing research

authors： Jung HH,Kim HJ,Im GJ,Chang J,Choi J,Chae SW

更新日期：2009-03-01 00:00:00

abstract：:Binaural temporal resolution was measured using the discrimination of brief interaural time delays (ITDs). In experiment 1, three listeners performed a 2I-2AFC, ITD-discrimination procedure. ITD changes of 8 to 1024micros were applied to brief probe noises. These probes, with durations of 16 to 362ms, were placed symm...

journal_title：Hearing research

authors： Kolarik AJ,Culling JF

更新日期：2009-02-01 00:00:00

abstract：:Test of amplitude modulation detection threshold against modulation frequency (Mf) is one of the major measures in behavior studies for exploring temporal acuity of the auditory system. In this experiment, we recorded cortical responses from implanted electrodes in guinea pigs to generate temporal modulation transfer ...

journal_title：Hearing research

authors： Feng Y,Yin S,Wang J

更新日期：2009-01-01 00:00:00

abstract：:Platelet-derived growth factor receptor (PDGFR) signaling has been demonstrated to play a pivotal role in early embryonic development. Although the expression of PDGF in the inner ear has been studied by RT-PCR, how PDGFR is involved there remains largely unclear. In the current study, we used the antagonistic anti-PD...

journal_title：Hearing research

authors： Hayashi H,Kunisada T,Takakura N,Aoki M,Mizuta K,Ito Y

更新日期：2008-11-01 00:00:00

abstract：:A critical issue in large-scale gene expression analysis is the impact of sexually dimorphic genes, which may confound the results when sampling across sexes. Here, we assessed, for the first time, sex differences at the transcriptome level in the auditory brainstem. To this end, microarray experiments covering the wh...

journal_title：Hearing research

authors： Ehmann H,Salzig C,Lang P,Friauf E,Nothwang HG

更新日期：2008-11-01 00:00:00

abstract：:Rodents have proven to be a useful model system to screen genes, ototoxic compounds and sound exposure protocols that may play a role in hearing loss. High-throughput screening depends upon a rapid and reliable functional assay for hearing loss. This study describes the use of a frequency modulated (FM) chirp stimulus...

journal_title：Hearing research

authors： Spankovich C,Hood LJ,Wesley Grantham D,Polley DB

更新日期：2008-11-01 00:00:00

abstract：:In developing neural prostheses, particular success has been realized with cochlear implants. These devices bypass damaged hair cells in the auditory system and electrically stimulate the auditory nerve directly. In contemporary cochlear implants, however, the injected electric current spreads widely along the scala t...

journal_title：Hearing research

authors： Richter CP,Bayon R,Izzo AD,Otting M,Suh E,Goyal S,Hotaling J,Walsh JT Jr

更新日期：2008-08-01 00:00:00

abstract：:Auditory prostheses use implanted electrode arrays that permit stimulation at many sites along the tonotopic axis of auditory neurons. Psychophysical studies demonstrate that measures of implant function, such as detection and discrimination thresholds, vary considerably across these sites, that the across-site patter...

journal_title：Hearing research

authors： Pfingst BE,Burkholder-Juhasz RA,Zwolan TA,Xu L

更新日期：2008-08-01 00:00:00

abstract：:A model was developed to simulate acoustically the effects of excitation spread in cochlear implants (CI). Based on neurophysiologic data, the proposed model simulates the electrical-current decay rate associated with broad and narrow types of excitation, such as those produced by monopolar and bipolar electrode confi...

journal_title：Hearing research

authors： Bingabr M,Espinoza-Varas B,Loizou PC

更新日期：2008-07-01 00:00:00

abstract：:The superior olivary complex (SOC) is a cluster of nuclei situated in the caudal brainstem tegmentum that forms an essential component of the auditory pathway. The SOC includes two principal nuclei, the medial and lateral superior olives (MSO and LSO respectively), that have clear roles in sound source localization. S...

journal_title：Hearing research

authors： Kulesza RJ Jr

更新日期：2008-07-01 00:00:00

abstract：:The focus of this study was to gauge the influence of intervening interference on an intensity standard held within auditory working memory through measurement of the just noticeable difference (JND) for intensity. Additionally, the use of interaural phase differences and interaural level differences as spatial cues w...

journal_title：Hearing research

authors： Jump RL,Ries DT

更新日期：2008-06-01 00:00:00

abstract：:Salicylate is a well-known substance to produce reversible tinnitus in animals and humans as well. It has been shown that systemic application of salicylate changes the neuronal spontaneous activity in several parts of the auditory pathway. The effects observed in central auditory structures in vivo could be based upo...

journal_title：Hearing research

authors： Basta D,Goetze R,Ernst A

更新日期：2008-06-01 00:00:00

abstract：:Following hair cell elimination in severely traumatized cochleae, differentiated supporting cells are often replaced by a simple epithelium with cuboidal or flat appearance. Atoh1 (previously Math1) is a basic helix-loop-helix transcription factor critical to hair cell differentiation during mammalian embryogenesis. F...

journal_title：Hearing research

authors： Izumikawa M,Batts SA,Miyazawa T,Swiderski DL,Raphael Y

更新日期：2008-06-01 00:00:00

abstract：:For the elevation and front-versus-back hemifield of a sound source to be accurately determined, the sound must contain a broad range of frequencies. Experiment 1 of this study examined the spectral integration time of the auditory localisation system by measuring the accuracy with which frequency-modulated (FM) tones...

journal_title：Hearing research

authors： Martin RL,McAnally KI

更新日期：2008-04-01 00:00:00

abstract：:Previous investigations have shown that a subset of inferior colliculus neurons, which have been designated type O units, respond selectively to isolated features of the cat's head-related transfer functions (HRTFs: the directional transformation of a free-field sound as it propagates from the head to the eardrum). Ba...

journal_title：Hearing research

authors： May BJ,Anderson M,Roos M

更新日期：2008-04-01 00:00:00

abstract：:Averaged auditory evoked potentials (AEPs) to bilaterally presented 100 Hz click trains were recorded from multiple sites simultaneously within Heschl's gyrus (HG) and on the posterolateral surface of the superior temporal gyrus (STG) in epilepsy-surgery patients. Three auditory fields were identified based on AEP wav...

journal_title：Hearing research

authors： Brugge JF,Volkov IO,Oya H,Kawasaki H,Reale RA,Fenoy A,Steinschneider M,Howard MA 3rd

更新日期：2008-04-01 00:00:00

abstract：:Mutations of the otoferlin gene have been shown to underlie deafness disorders in humans and mice. Analyses of genetically engineered mice lacking otoferlin have demonstrated an essential role for this protein in vesicle exocytosis at the inner hair cell afferent synapse. Here, we report on the molecular and phenotypi...

journal_title：Hearing research

authors： Longo-Guess C,Gagnon LH,Bergstrom DE,Johnson KR

更新日期：2007-12-01 00:00:00

abstract：:Sensorineural hearing loss, which is often caused by degeneration of hair cells in the auditory epithelium, is permanent because lost hair cells are not replaced. Several conceptual approaches can be used to place new hair cells in the auditory epithelium. One possibility is to enhance proliferation of non-sensory cel...

journal_title：Hearing research

authors： Minoda R,Izumikawa M,Kawamoto K,Zhang H,Raphael Y

更新日期：2007-10-01 00:00:00

abstract：:The purpose of this study is to: (1) examine the relative contributions of the 13 acoustically-responsive regions of the cerebral cortex to sound localization; (2) examine the laminar contributions to spatial localization behavior for each of the cortical areas identified to be critical for accurately determining the ...

journal_title：Hearing research

authors： Lomber SG,Malhotra S,Hall AJ

更新日期：2007-07-01 00:00:00

abstract：:Potassium channels play a critical role in defining the electrophysiological properties accounting for the unique response patterns of auditory neurons. Serial analysis of gene expression (SAGE), microarrays, RT-PCR, and real-time RT-PCR were used to generate a broad profile of potassium channel expression in the rat ...

journal_title：Hearing research

authors： Friedland DR,Eernisse R,Popper P

更新日期：2007-06-01 00:00:00

abstract：:Nitric oxide (NO) production during hyposmotic stimulation in outer hair cells (OHCs) of the guinea pig cochlea was investigated using the NO sensitive dye DAF-2. Simultaneous measurement of the cell length and NO production showed rapid hyposmotic-induced cell swelling to precede NO production in OHCs. Hyposmotic sti...

journal_title：Hearing research

authors： Takeda-Nakazawa H,Harada N,Shen J,Kubo N,Zenner HP,Yamashita T

更新日期：2007-05-01 00:00:00

abstract：:During normal development, cells divide, then differentiate to adopt their individual form and function in an organism. Under most circumstances, mature cells cannot transdifferentiate, changing their fate to adopt a different form and function. Because differentiated cells cannot usually divide, the repair of injurie...

journal_title：Hearing research

authors： Batts SA,Raphael Y

更新日期：2007-05-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations/deletions are considered to be associated with the development of age-related hearing loss (AHL). We assessed the role of accumulation of mtDNA mutations in the development of AHL using Polg(D257A) knock-in mouse, which exhibited increased spontaneous mtDNA mutation rates during agi...

journal_title：Hearing research

authors： Yamasoba T,Someya S,Yamada C,Weindruch R,Prolla TA,Tanokura M

更新日期：2007-04-01 00:00:00